National Water Quality Laboratory

Friday October 19, 2018

Analytical Chemistry

Trace Analysis of Antidepressant Pharmaceuticals and their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS

Melissa M. Schultz and Edward T. Furlong

December 2007

Treated wastewater effluent is a potential environmental point source for antidepressant pharmaceuticals. A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography-electrospray ionization tandem mass spectrometry. Recoveries of parent antidepressants from matrix spiking experiments for the individual antidepressants ranged from 72 to 118% at low concentrations (0.5 ng/L) and 70 to 118% at high concentrations (100 ng/L) for the solid-phase extraction method. Method detection limits for the individual antidepressant compounds ranged from 0.19 to 0.45 ng/L. The method was applied to wastewater effluent and samples collected from a waste-water-dominated stream. Venlafaxine was the predominant antidepressant observed in wastewater and river water samples. Individual antidepressant concentrations found in the wastewater effluent ranged from 3 (duloxetine) to 2190 ng/L venlafaxine), whereas individual concentrations in the waste-dominated stream ranged from 0.72 (norfluoxetine) to 1310 ng/L (venlafaxine).

VIEW the report. (pdf)

Accessibility FOIA Privacy Policies and Notices

U.S. Department of the Interior | U.S. Geological Survey
Page Contact Information: NWQL LabHelp
Page Last Modified: Wednesday, 03-May-2017 08:34:31 MDT